C1 Expression System

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Filamentous Myceliophthorathermophila C1 is a newly raised fungal expression system, which can be used for various proteins production including enzymes and biologic medicines. It is very efficient in protein secretion, and can be easily cultured to high cell densities on relatively low-cost medium. Profacgen provides enzymes and biologic drug production services using C1 systems for scientist in academia and various industries.

Features

Achieve very high yield
Produce proteins that are much purer than traditional production systems
Save time on production compared with other eukaryotic system, such as CHO
Show robustness under different temperature and pH

C1 is classified as Myceliophthorathermophila isolate, previously known as Chrysosporium lucknowense.

It shows a low-viscosity morphology in culture, which further enable C1’s application in high-throughput robotic screening of gene libraries.

Unlike chemical drugs that can be synthesized in a laboratory, biologic drug, or biologics, can only be manufactured in living cells. Hyper productive C1 expression system is perfect for production of biologics. Recombinant C1 strains were engineered to produce biologics and enzymes for commercial applications. C1-technology platform has been applied as a tool for research and industries. The low-viscosity morphology of C1 enable its use in high throughput screening procedure.

C1 can minimize the cost and overcome the limitations of traditional eukaryotic production systems. It delivers higher purity of protein and is highly robust. Hyper productive strains have been developed for various industrial applications. Production has been approved as safe by FDA. Profacgen dedicate itself to provide contracted biologic drug production service for customers in pharmaceutical industry, as well as research institutions. Please do not hesitate to inquire to see what we can do for you!

Reference

Visser H., (2011). Development of a mature fungal technology and production platform for industrial enzymes based on a Myceliophthora therophila isolate, previously known as Chrysosporium lucknowense C1. Research. 7(3): 214-223.

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