A New Temperature-Responsive Vehicles for Drug Delivering

Drug delivery has always been an eternal topic in pharmaceutical research and development. Whether it is chemical drugs or biological drugs, almost all medicines will face the problem of drug delivery. Drug delivery affects how the final drug exerts its efficacy and even becomes the critical point determining drug development's success or failure. The polymer-based delivery system is currently the most widely used and relatively innovative delivery method. Using dendrimer, polylactic acid-glycolic acid copolymer (PLGA), and other high molecular polymers as the carrier, the RNA drug is wrapped in it for delivery, which has biodegradability, biocompatibility, high water solubility, and storage stability and other physicochemical properties, it is considered as an ideal drug delivery material. There are two types of targeting strategies based on polymer delivery systems: passive targeting and active targeting. Passive targeting regulates the size, morphology, structure, surface properties, and other physical and chemical properties of polymers to make them independent of the target. The ability to recognize molecules can enter specific organelles, cells, tissues, or organs. Active targeting refers to the entry of polymers into specific organelles, cells, tissues, or organs through the recognition ability of their surface-modified targeting molecules. However, many polymers cannot be degraded after performing their function, which can lead to potential adverse side effects. Therefore, it is necessary to produce temperature-responsive, biodegradable polymers for drug delivery and cancer therapy.

Recently, researchers have developed a new drug delivery platform by conjugating drugs with polyacetal. The platform can more easily target the site of temperature change through the temperature response. In addition, the polymer can be biodegraded and can be degraded into neutral substances under acidic conditions. This non-toxic degradation product can be effectively taken out of the body without causing side effects. In addition to this, the platform exhibits a deficient critical solution temperature behavior, which is very controllable. These polymeric carriers are soluble in plasma at physiological temperatures. Still, they become insoluble above target temperatures (i.e., 41-43°C for hypothermic tumors), enabling them to target and accumulate in hyperthermic regions such as tumors preferentially. This platform provides new materials for drug delivery and demonstrates the great potential of processing in drug release efficiency.

The Advantages of this platform include:

• Reduced side effects
• Biodegradable and non-toxic
• Degradation conditions are controllable
• Easy to synthesize
• Temperature-sensitive

Potential Applications

• Development of drug delivery materials
• Research on cancer treatment

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Reference

1. Sánchez-Purrà, Maria. (2015). Development of novel vesicle-like nanocarriers for targeted drug delivery. 10.13140/RG.2.2.15538.30407.