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Recombinant Human MSR1 Protein (His tag) (HI0026MS)

Recombinant Human MSR1 Protein (NP_619729) (77-451aa) with C-terminus His tag was expressed in Insect cells.
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Size:50ug
Price:$450.00
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PRODUCT INFORMATION
Cat.No.
HI0026MS
Synonyms
MSR1; CD204; SCARA1; SRA; SR-A; phSR1; phSR2;
Species
Human
Accession
Source
Insect cells
Tag
His tag
Form
In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass
42.4kDa (384aa)
40-57KDa (SDS–PAGE under reducing conditions.)
AA Sequence
ADPKWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ
WGTRACSHSE DAGVTCTLHH HHHH
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE

Usage Guide
Storage
Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration
0.5mg/ml (determined by Absorbance at 280nm)
Warning
For research use only!

BACKGROUND
Background
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
References
Dansako H., et al. (2013) PLoS Pathog. 9:E1003345.
Shigeoka M., et al. (2013) Cancer Sci. 104:1112-1119.

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