Transporters are a group of specialized membrane proteins that power the translocation of numerous substances, including essential nutrients, ions, neurotransmitters, cellular waste and environmental toxins, across the cellular membrane. Many transporters have emerged as therapeutic targets for diseases such as depression, schizophrenia, cancer, and diabetes. Therefore, transporter screening for therapeutically effective and safe compounds has become very important in the discovery and development of transporter-targeted drugs.
Schematic Diagram of Transporters 
Profacgen provides specialized transporter panels and customized transporter screening services enabling you to identify novel transporter-targeted compounds. Our transporter panels include FDA transporter screening panel, monoamine transporter models and many other cell models. We employ robust transporter uptake and inhibition assays to perform quick and cost-effective screening of new molecular entities (NMEs) for their interactions with transporters, and offer you results with good signal-to-background ratio and Z’ scores.
Please feel free to contact us for more details about our customized transporter screening service.
Profacgen offers transporter targets that have great significance in clinical therapy, such as ATP binding cassette transporter (P-gp), neurotransmitter (SERT, DAT, NET), and solution carrier family transporter (SLC13). Our assay methods include radio-isotopic detection, fluorescence detection and ion flux detection.
See the instruction of transporter screening service. Find the targets list available in our screening service and the assay format we could provide to you.
Click here to download the Service Instruction.
 G. Diallinas. Understanding Transporter Specifity and the Discrete Appearance of Channel-Like Gating Domains in Transporters. Front Pharmacol, 2014, 12 (5): 207.