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• Recombinant Protein or Antibody Production • Protein Expression Systems > Bacterial Expression Systems(E. coli / Bacillus) > Yeast Expression Systems(P pastoris / S cerevisiae) > Baculovirus-insect Cell Expression Systems > Mammalian Expression Systems(CHO / 293) • PEGylation Services • Stable Cell Line Construction for Protein Expression • Process Development • cGMP Manufacturing • QC and QA • Bacterial Manufacturing • Bacteria Expression • Yeast Expression • Mammalian Cell Expression • Insect Cell Expression • Animal-free Expression • Cell-free protein expression • Large-scale Protein Production • PEGylation Services • Basic Protein Characterization • Protein Labeling • Stable Cell Line Construction for Protein Expression • Protein Mutagenesis • Protein Interaction Analysis Services > Yeast Two-Hybrid Screening > Membrane-based Yeast Two-Hybrid Screening > Co-Immunoprecipitation (Co-IP) > Surface plasmon resonance (SPR) Service > Pull Down Assay > Bio-layer Interferometry (BLI) Service • Yeast Two-Hybrid Screening • Membrane-based Yeast Two-Hybrid Screening • Co-Immunoprecipitation (Co-IP) • Surface plasmon resonance (SPR) Service • Pull Down Assay • Protein Mutant Library Construction • Enzyme Target & Activator & Inhibitor Screening Service • GPCR Screening Service • Ion Channel Screening Service • Bio-layer Interferometry (BLI) Service • Electrophoretic Mobility Shift Assay (EMSA) Service • Transcription Factor Analysis > Electrophoretic Mobility Shift Assay (EMSA) Service > Chromatin Immunoprecipitation (ChIP) Assay Service > DNase I Footprinting Assay Service • Transporter Screening Service • Chromatin Immunoprecipitation (ChIP) Assay Service • Enzyme Activity Assay Service • DNase I Footprinting Assay Service • Protein Expression > Custom Lysate Preparation Service > C1 Expression System • Protein Biotinylation Service • Custom Lysate Preparation Service • Immunogenicity Test Service > Anti-Drug Antibody (ADA) Evaluation Service > Neutralizing Antibody (NAb) Test Service • Anti-Drug Antibody (ADA) Evaluation Service • Neutralizing Antibody (NAb) Test Service • Thanksgiving Day Sale • C1 Expression System • Protein Conjugation Service on Beads

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PEGylation Services


PEGylation is the process of attaching polyethylene glycol (PEG) polymer chains to target molecules to monitor their physiochemical properties. Various PEG moieties have been developed for different purposes.

Features

  Highly site-specific modifications.
  Improved target solubility and stability.
  Reduced immunogenicity and toxicity.
  Enhanced protection from proteolytic degradation.
  Increased in vivo efficacy and clinical effectiveness.
PEGylation Services

Polyethylene glycol, which is often abbreviated to PEG, is a chemical compound composed of repeated ethylene glycol units. PEG possesses several chemical properties that facilitate target protein's fuctions in diverse biological and pharmaceutical applications.

PEGylated proteins show great advantage over non-PEGylated proteins in terms of non-toxicity, low immunogenicity, high solubility and mobility in solution. PEGylation was also found to be able to mask the target protein drugs from the host’s immune system. The established therapeutic value and high flexibility of PEGylation made it a valuable tool in efficient drug development.

Profacgen has developed a series of technologies to increase the site-specificity of our PEGylation process. You can choose from the following according to your specific requirements or we can help recommend the best procedure for you!

PEGylation Services

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