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• Protein Biotinylation Service • Custom Lysate Preparation Service • Immunogenicity Test Service > Anti-Drug Antibody (ADA) Evaluation Service > Neutralizing Antibody (NAb) Test Service • Anti-Drug Antibody (ADA) Evaluation Service • Neutralizing Antibody (NAb) Test Service • Thanksgiving Day Sale • Enzyme Target & Activator & Inhibitor Screening Service • GPCR Screening Service • Ion Channel Screening Service • Bio-Layer Interferometry (BLI) • Electrophoretic Mobility Shift Assay (EMSA) Service • Transcription Factor Analysis > Electrophoretic Mobility Shift Assay (EMSA) Service > Chromatin Immunoprecipitation (ChIP) Assay Service > DNase I Footprinting Assay Service • Transporter Screening Service • Chromatin Immunoprecipitation (ChIP) Assay Service • Enzyme Activity Assay Service • DNase I Footprinting Assay Service • Co-Immunoprecipitation (Co-IP) • Surface Plasmon Resonance (SPR) Service • Pull Down Assay • Protein Mutant Library Construction • C1 Expression System • Protein Conjugation Service on Beads • Bacteria Expression • Yeast Expression • Mammalian Cell Expression • Insect Cell Expression • Animal-Free Expression • Cell-Free Protein Expression • Large-Scale Protein Production • PEGylation Products and Services > Custom PEGylation Services > PEGylation Products • Basic Protein Characterization • Protein Labeling • Stable Cell Line Construction for Protein Expression • Protein Mutagenesis • Protein Interaction Analysis Services > Bio-Layer Interferometry (BLI) > Co-Immunoprecipitation (Co-IP) > Surface Plasmon Resonance (SPR) Service > Pull Down Assay > Yeast Two-Hybrid Screening > Membrane-Based Yeast Two-Hybrid Screening > CLIP-Seq Service > Protein Binding Site Mapping > Isothermal Titration Calorimetry > Membrane Protein Binding Screening and Profiling • Yeast Two-Hybrid Screening • Membrane-Based Yeast Two-Hybrid Screening • Recombinant Protein or Antibody Production • Protein Expression Systems > Nicotiana Tabacum Expression System > Bacterial Expression Systems(E. coli / Bacillus) > Yeast Expression Systems(P pastoris / S cerevisiae) > Baculovirus-insect Cell Expression Systems > Mammalian Expression Systems(CHO / 293) • PEGylation Services • Stable Cell Line Construction for Protein Expression • Process Development • cGMP Manufacturing • QC and QA • Bacterial Manufacturing • CLIP-Seq Service • Protein Binding Site Mapping • Quantum Dot Labeling • Protein Expression > Custom Lysate Preparation Service > C1 Expression System > Protein Co-Expression Service in E. coli System > Protein Co-Expression Service in Mammalian Cells > Trimeric Protein Production Service > Lettuce Transient Expression System • Protein Co-Expression Service in E. coli System • Protein Co-Expression Service in Mammalian Cells • NovEgg Expression System • ADME/Tox Prediction • Pharmacophore Modeling • Screening and Profiling Services > Enzyme Target & Activator & Inhibitor Screening Service > GPCR Screening Service > Ion Channel Screening Service > Transporter Screening Service • Trimeric Protein Production Service • Incorporation of Bioorthogonal Handles > Incorporation of Unnatural Amino Acids > Incorporation of Unnatural Sugars > Direct Chemical Modification • Incorporation of Unnatural Amino Acids • Incorporation of Unnatural Sugars • Protein/Peptide Crosslinking > Enzymatic Crosslinking Services > Photocrosslinking Services > Chemical Crosslinking Services • Enzymatic Crosslinking Services • Photocrosslinking Services • Chemical Crosslinking Services • Direct Chemical Modification • Protein-Fluorophore Bioconjugation • Custom PEGylation Services • PEGylation Products • Target Protein Degradation - Proteolysis Targeted Chimera (PROTAC) • Induced Protein Degradation > Target Protein Degradation - Proteolysis Targeted Chimera (PROTAC) > Hydrophobic Tag Services > Destabilization Domains (DDs) • Hydrophobic Tag Services • Destabilization Domains (DDs) • Drug Development • Protein Analysis > Cell-based Kinase Assays > Protein Aggregation Analysis • Protein Production > Anaerobic Fermentation • Anaerobic Fermentation > Lactic Acid Bacteria Fermentation • Cell-based Kinase Assays • Isothermal Titration Calorimetry • Lactic Acid Bacteria Fermentation • Protein Aggregation Analysis Nicotiana Tabacum Expression System • Lettuce Transient Expression System • Membrane Protein Binding Screening and Profiling

CONTACT US

Tel: 1-631-448-8149
Fax: 1-631-938-8127

Custom PEGylation Services

Profacgen provides a comprehensive set of PEGylation services for proteins, peptides, oligonucleotides and small molecules, and custom synthesis of PEG derivatives. Conjugation of PEGs has been shown to be a powerful tool in solubilizing biomolecules, reducing immunogenicity of ADCs, increasing circulation stability of drugs. It is also widely used in material science, cosmetic science and other industrial applications.

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Protein/peptide-PEG conjugation

PEGylation of proteins and peptides provides a number of advantages, such as reduction or elimination of immunogenicity and mitigation of aggregation. In part, the big success of PEG-related applications is due to the large selection of commercially available PEG products and the well-developed PEGylation strategies. However, it is also difficult to draw a general guideline for conducting PEGylation experiments since oftentimes case-by-case optimization is needed. The chemists at Profacgen are specialized in protein bioconjugation and PEGylation, and they will help you find the right PEGylation strategy for your unique projects.

Small-molecule PEGylation

PEGs are generally attached to small-molecule drugs to alter their pharmacokinetic properties. They can be made into different shapes (i.e., linear, branched or forked) and attached at different sites, creating new compounds or prodrugs. The linker between drugs and PEG fragments can be either stable or releasable depending on the purpose of the application. Stable linkers tend to create new pharmaceutical entities in terms of changing parameters such as half-life, bioavailability and clearance rate. For your convenience, we deliver one-stop service that covers reagent supply, protein expression, peptide synthesis, PEGylation and product purification and characterization.

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PEGylated doxorubicin

 

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PEGylated 10-amino-7-ethyl camptothecin

 

Custom synthesis of PEGs

In addition to our diversified product line, we also welcome specific requests from our customers. Profacgen delivers custom synthesis of innovative PEGylation reagents and derivatives to meets the unique requirements of your projects. Services may include:

  • Installation of reactive groups toward amino acids other than cysteine and lysine;
  • PEG derivatives containing bioorthogonal handles, e.g., azide and alkyne;
  • PEGs with specific length and number of arms.

For more information regarding Profacgen’s PEGylation services, please contact usor call 1-631-448-8149. Our customer service representatives are available 24 hours a day, Monday through Friday, to assist you.

CONTACT US
Email: info@profacgen.com
Tel: 1-631-448-8149
Fax: 1-631-938-8127
Address: 45-1 Ramsey Road, Shirley, NY 11967, USA