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• Protein Biotinylation Service • Custom Lysate Preparation Service • Immunogenicity Test Service > Anti-Drug Antibody (ADA) Evaluation Service > Neutralizing Antibody (NAb) Test Service • Anti-Drug Antibody (ADA) Evaluation Service • Neutralizing Antibody (NAb) Test Service • Thanksgiving Day Sale • Enzyme Target & Activator & Inhibitor Screening Service • GPCR Screening Service • Ion Channel Screening Service • Bio-layer Interferometry (BLI) Service • Electrophoretic Mobility Shift Assay (EMSA) Service • Transcription Factor Analysis > Electrophoretic Mobility Shift Assay (EMSA) Service > Chromatin Immunoprecipitation (ChIP) Assay Service > DNase I Footprinting Assay Service • Transporter Screening Service • Chromatin Immunoprecipitation (ChIP) Assay Service • Enzyme Activity Assay Service • DNase I Footprinting Assay Service • Co-Immunoprecipitation (Co-IP) • Surface plasmon resonance (SPR) Service • Pull Down Assay • Protein Mutant Library Construction • C1 Expression System • Protein Conjugation Service on Beads • Bacteria Expression • Yeast Expression • Mammalian Cell Expression • Insect Cell Expression • Animal-free Expression • Cell-free protein expression • Large-scale Protein Production • PEGylation Products and Services > Custom PEGylation Services > PEGylation Products • Basic Protein Characterization • Protein Labeling • Stable Cell Line Construction for Protein Expression • Protein Mutagenesis • Protein Interaction Analysis Services > Bio-layer Interferometry (BLI) Service > Co-Immunoprecipitation (Co-IP) > Surface plasmon resonance (SPR) Service > Pull Down Assay > Yeast Two-Hybrid Screening > Membrane-based Yeast Two-Hybrid Screening > CLIP-Seq Service > Protein Binding Site Mapping • Yeast Two-Hybrid Screening • Membrane-based Yeast Two-Hybrid Screening • Recombinant Protein or Antibody Production • Protein Expression Systems > Nicotiana tabacum Expression System > Bacterial Expression Systems(E. coli / Bacillus) > Yeast Expression Systems(P pastoris / S cerevisiae) > Baculovirus-insect Cell Expression Systems > Mammalian Expression Systems(CHO / 293) • PEGylation Services • Stable Cell Line Construction for Protein Expression • Process Development • cGMP Manufacturing • QC and QA • Bacterial Manufacturing • CLIP-Seq Service • Protein Binding Site Mapping • Quantum Dot Labeling • Protein Expression > Custom Lysate Preparation Service > C1 Expression System > Protein Co-expression Service in E. coli System > Protein Co-expression Service in Mammalian Cells > Trimeric Protein Production Service • Protein Co-expression Service in E. coli System • Protein Co-expression Service in Mammalian Cells • NovEgg Expression System • ADME/Tox Prediction • Pharmacophore Modeling • Screening and Profiling Services > Enzyme Target & Activator & Inhibitor Screening Service > GPCR Screening Service > Ion Channel Screening Service > Transporter Screening Service • Trimeric Protein Production Service • Incorporation of Bioorthogonal Handles > Incorporation of Unnatural Amino Acids > Incorporation of Unnatural Sugars > Direct Chemical Modification • Incorporation of Unnatural Amino Acids • Incorporation of Unnatural Sugars • Protein/peptide Crosslinking > Enzymatic Crosslinking Services > Photocrosslinking Services > Chemical Crosslinking Services • Enzymatic Crosslinking Services • Photocrosslinking Services • Chemical Crosslinking Services • Direct Chemical Modification • Protein-fluorophore Bioconjugation • Custom PEGylation Services • PEGylation Products • Target Protein Degradation - Proteolysis Targeting Chimera (PROTAC) • Induced Protein Degradation > Target Protein Degradation - Proteolysis Targeting Chimera (PROTAC) > Hydrophobic Tag Services > Destabilization Domains (DDs) • Hydrophobic Tag Services • Destabilization Domains (DDs) Nicotiana tabacum Expression System

CONTACT US

Tel: 1-631-448-8149
Fax: 1-631-938-8127

Process Development Service

Profacgen is capable of providing process development service for our customers. We have extensive expertise in all aspects of upstream and downstream development of protein drug/product manufacturing process, which facilitates your preclinical drug development process. We guarantee the well-defined, scalable and reproducible processes of making successful protein products are undertaken in a commercially viable and regulatory compliant way.

Process Development Service

In general, Process Development service involves cell line development and selection, upstream process development, and downstream purification process development. At Profacgen, we can screen among production strains to select an appropriate cell line that will efficiently produce your drug candidate. We also develop processes to optimize high cell density fermentation, to increase protein product yield and manufacture product of the best quality in the most efficient way possible. Besides, our service aims to improve product recovery processes, as well as downstream purification steps. 

Our Process Development Service covers: 

  Cell line selection and characterization
  Cell line quality assessment
  Culture media evaluation and optimization
  Batch, fed-batch, or perfusion process development
  Seed train/inoculum development
  Scale-up and viral clearance

 

We have extensive experience and capability to design, develop, optimize and troubleshoot for all stages of process development with a variety of approaches.

 

Equipment & Capabilities:

  Multiple bioreactors from 1L to 20L in mammalian or microbial systems.
  Chromatography utilizing AKTA explore system.
  Filtration unites for downstream applications.
  Cell banking services for production and cryopreservation.

 

Please contact us for more details of our preclinical process development services. Our experts will provide and help design an optimal solution for your project and trouble-shoot for you throughout the whole process.

 

CONTACT US
Email: info@profacgen.com
Tel: 1-631-448-8149
Fax: 1-631-938-8127
Address: 45-1 Ramsey Road, Shirley, NY 11967, USA