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• Protein Biotinylation Service • Custom Lysate Preparation Service • Immunogenicity Test Service > Anti-Drug Antibody (ADA) Evaluation Service > Neutralizing Antibody (NAb) Test Service • Anti-Drug Antibody (ADA) Evaluation Service • Neutralizing Antibody (NAb) Test Service • Thanksgiving Day Sale • Enzyme Target & Activator & Inhibitor Screening Service • GPCR Screening Service • Ion Channel Screening Service • Bio-layer Interferometry (BLI) Service • Electrophoretic Mobility Shift Assay (EMSA) Service • Transcription Factor Analysis > Electrophoretic Mobility Shift Assay (EMSA) Service > Chromatin Immunoprecipitation (ChIP) Assay Service > DNase I Footprinting Assay Service • Transporter Screening Service • Chromatin Immunoprecipitation (ChIP) Assay Service • Enzyme Activity Assay Service • DNase I Footprinting Assay Service • Co-Immunoprecipitation (Co-IP) • Surface plasmon resonance (SPR) Service • Pull Down Assay • Protein Mutant Library Construction • C1 Expression System • Protein Conjugation Service on Beads • Bacteria Expression • Yeast Expression • Mammalian Cell Expression • Insect Cell Expression • Animal-free Expression • Cell-free protein expression • Large-scale Protein Production • PEGylation Services • Basic Protein Characterization • Protein Labeling • Stable Cell Line Construction for Protein Expression • Protein Mutagenesis • Protein Interaction Analysis Services > Bio-layer Interferometry (BLI) Service > Co-Immunoprecipitation (Co-IP) > Surface plasmon resonance (SPR) Service > Pull Down Assay > Yeast Two-Hybrid Screening > Membrane-based Yeast Two-Hybrid Screening > CLIP-Seq Service > Protein Binding Site Mapping • Yeast Two-Hybrid Screening • Membrane-based Yeast Two-Hybrid Screening • Recombinant Protein or Antibody Production • Protein Expression Systems > Nicotiana tabacum Expression System > Bacterial Expression Systems(E. coli / Bacillus) > Yeast Expression Systems(P pastoris / S cerevisiae) > Baculovirus-insect Cell Expression Systems > Mammalian Expression Systems(CHO / 293) • PEGylation Services • Stable Cell Line Construction for Protein Expression • Process Development • cGMP Manufacturing • QC and QA • Bacterial Manufacturing • CLIP-Seq Service • Protein Binding Site Mapping • Quantum Dot Labeling • Protein Expression > Custom Lysate Preparation Service > C1 Expression System > Protein Co-expression Service in E. coli System > Protein Co-expression Service in Mammalian Cells > Trimeric Protein Production Service • Protein Co-expression Service in E. coli System • Protein Co-expression Service in Mammalian Cells • NovEgg Expression System • ADME/Tox Prediction • Pharmacophore Modeling • Screening and Profiling Services > Enzyme Target & Activator & Inhibitor Screening Service > GPCR Screening Service > Ion Channel Screening Service > Transporter Screening Service • Trimeric Protein Production Service Nicotiana tabacum Expression System

CONTACT US

Tel: 1-631-448-8149
Fax: 1-631-938-8127

Computational Protein Analysis

Proteins play key roles in almost all biological pathways in a living system, and their functions are determined by the three-dimensional shape of the folded polypeptide chain. Advances in DNA sequencing and structural biology over the years have revolutionized our understanding of structure-function relationship of these macromolecules. Especially, an increased number of protein structures in the Protein Data Bank have provided invaluable information about the precise position of each atom, which allows for the understanding of the protein structures and cellular machinery at atomic level and facilitates the discovery of therapeutic drugs. Complementary to experimental methods, in silico approaches can reveal additional information related to many aspects of the protein structure-function relationship, which could be masked by the static picture of the protein configuration.

At Profacgen, we utilize the most state-of-the-art computer software tools that enable comprehensive analyses for a protein by integrating both sequence data and structural information. Our experienced bioinformatics team can help reveal various features of the protein of interest, including but not limited to:

  • Physico-chemical parameters
  • Annotation of protein functions
  • Homology detection and structural alignment
  • Motif discovery
  • Functional/binding sites analysis and calculation of cavity volume
  • Global topological analysis and local structure characterization
  • Identification of surface/interface contact map
  • Mapping of H-bonding networks
  • Electrostatics calculation
  • Hydrophobic cluster analysis
  • Evaluation of protein stability/folding energy
  • Prediction of protein intrinsic disorder
  • Estimation of structure quality and error correction
  • Sequence- and structure-based PPI networks

We attempt to accurately characterize proteins in silico and to provide insights into the functions based on information such as their sequence, structure, dynamics, evolutionary history, and their association with other molecules. The results will offer an explanation of observed experimental data from a computational biology perspective, or serve as a guide for further lab experiments.

Computational protein analysis

Computational Protein Analysis

 

Features

  Fast turnaround time
  Detailed project report usually within a week
  A variety of computational analyses available
  Customized analysis as requested
  Assistance in identifying appropriate software tools
  Experts available for technical consultation and experimental design

 

We promise to offer customized service according to the specific need of our customers’ and integrate our computational procedures into your workflow. Please do not hesitate to contact us for more details about our computational protein analysis service.

CONTACT US
Email: info@profacgen.com
Tel: 1-631-448-8149
Fax: 1-631-938-8127
Address: 45-1 Ramsey Road, Shirley, NY 11967, USA