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PROTAC in Animal Model

PROTAC in Animal Model

PROTAC is small molecule that can be a potential drug with the degradation function targeted disease-causing proteins. For drug development process, in animal model tests are very important for optimization and safety assessment. Furthermore, laws worldwide currently require that candidate drugs are tested on animals before clinical trials on humans.

For half a century, in a large majority of drugs have been tested by studies in mice, rats, dogs, monkeys and other animal species which have led to suggestions for drugs to be tested in patients. The types of animal model tests performed including eye irritancy, acute toxicity, repeated dose toxicity, irritation, skin sensitization, pharmacokinetics/ toxic kinetics and metabolism, dermal penetration, mutagenicity, carcinogenicity, reproductive and developmental toxicity, neurotoxicity, ecotoxicity, pyrogenicity and so on. The animal test results are not always translated into effective drugs, but the failures themselves have helped to reformulate the model and experimental conditions or give an insight into the type of chemical.

Profacgen offers different animal tests for PROTACs:

  • ADME evaluation - absorption, distribution, metabolism and excretion.
  • Toxicology evaluation - acute toxicity, repeated dose toxicity, development and reproductive toxicity, carcinogenicity, immunogenicity, anti-drug antibody and neutralizing antibody.
  • Pharmacokinetics determination - release process, half-life and dosing interval.
  • Stimulation test – in blood, vessels, muscles, eyes and skin.
  • Hypersensitivity test - active allergy and passive allergy.

Advantages of our services:

  • Multiple animal species and wide range of assays.
  • Professional team and customized services.
  • Detailed data and reliable analysis.
  • Short turnaround time and cost-effective pricing.

Profacgen is experienced in providing animal tests for facilitating PROTAC development to clinical stages. Please contact us for more information.

References:

1. Garattini S, Grignaschi G. (2017). Animal testing is still the best way to find new treatments for patients. European Journal of Internal Medicine, 39, 32–35. doi:10.1016/j.ejim.2016.11.013
2. Prasad ChB. (2016). A Review on Drug Testing in Animals. Translational Biomedicine, 7:4. doi:10.2167/2172-0479.100099

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