Targeted Protein Degradation

As one of the well-known service providers in biotechnology field, Profacgen keeps in step with cutting-edge biological research orientation and quickly responds to customer demands for new methods and techniques. Here, we provide personalized targeted protein degradation services against the proteins of interest (POIs).

Hydrophobic Tag

Destabilization Domains

Targeted protein degradation is an emerging inhibition of strategy aiming at POIs, especially as a promising therapeutic strategy for drug discovery, through different methods to redirect the cellular protein homeostasis machinery. As part of cellular processes, POIs are specifically recruited to E3 ubiquitin ligases and tagged for destruction with chains of ubiquitin. These ubiquitin chains are used to target proteins to the proteasome, where they are unfolded and digested.

Figure 1 Summary of the ubiquitin system

Compared to inhibition strategies, degradation offers numerous advantages, including the chance to remove the target protein and consequent ablation of all associated functions. The unique properties of degraders present opportunities for differentiated therapeutics, as well as the chance to tackle pathologies driven by proteins those were previously considered inaccessible to small-molecule intervention proteins described as ‘undruggable’.

Profacgen’s targeted protein degradation team, based on many years of experience in basic and applied research in biochemistry and structural biology, is confident in delivering an optimal solution to help you succeed in your research projects. Please do not hesitate to contact us for more details of targeted protein degradation services. Our expert representatives are available 24 hours a day, Monday through Friday, to assist you.