RNA-binding proteins (RBPs) play important roles in the regulation of gene expression through a variety of post-transcriptional mechanisms,which physically to regulate each other's life cycle and function. The mRNA coding sequence guides the synthesis of proteins and some regulatory sequences, while the untranslated region of mRNA affects the fate of the encoded protein by regulating the translation, positioning, and interaction with other proteins. On the other hand, from RNA synthesis to degradation, proteins can in turn bind and regulate RNA expression and function. The interaction of RNA and protein is very important to maintain the homeostasis of the cell, and interfering with the interaction of the two will cause cell dysfunction and related diseases.
There are many ways to study and identify the interaction between RNA and protein. Profacgen provides RNA-centricand protein-centric research methods. The former is based on the RNA of interest to find the protein to which it binds, and can be divided into two types of research methods in vivo and in vitro; the latter is based on the protein of interest to find the RNAs to bind to, which can be divided into two types of research methods based on CLIP and non-CLIP principles.
Profacgen has a professional team for studying RNA-protein interactions. We welcome you to consult, and sincerely invites laboratories to cooperate and develop together.