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Recombinant Rat Tgfb1 Protein (RH0264TL)

Recombinant Rat Tgfb1 Protein (P04202) (Ala279-Ser390) with no tag was expressed in HEK293.
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PRODUCT INFORMATION
Cat.No.
RH0264TL
Synonyms
TGFB1; TGF-beta-1; Tgfb
Species
Rat
Accession
Source
HEK293
Predicted N Terminal
Ala 279
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Bio-activity
Measured by its ability to inhibit the proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is 0.02-0.08ng/mL.
Molecular Mass
Recombinant Rat TGFB1 comprises 112 amino acids and predicts a molecular mass of 12.8 kDa.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 90 % by SDS-PAGE.

Usage Guide
Storage
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.
Reconstitution
Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.
Warning
For research use only!

BACKGROUND
Background
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (PubMed:22781750). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).

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