Recombinant Cynomolgus IL23R Protein(Fc tag) (CH0272IL)

Recombinant Cynomolgus IL23R Protein (F6XR82) (Met1-Asp353) with the Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Datasheet

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50ug	$429.00

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PRODUCT INFORMATION

Cat.No.

CH0272IL

Synonyms

IL23R; IL-23R; IBD17

Species

Cynomolgus

Accession

IL23R

Source

HEK293

Tag

Predicted N Terminal

Gly 24

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 μg/ml. Immobilized mouse mIL12Bh (m)+mIL23Ah at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.05-0.11 μg/ml.

Molecular Mass

Recombinant Cynomolgus IL23R comprises 571 amino acids and has a calculated molecular mass of 64.9 KDa.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 90 % by SDS-PAGE.

BACKGROUND

Background

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).

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