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Recombinant Human CTLA4 Protein (His tag) (HI0027CS)

Recombinant Human CTLA4 Protein (NP_005205) (36-161aa) with C-terminus His tag was expressed in Insect cells.
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Size:50ug
Price:$450.00
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PRODUCT INFORMATION
Cat.No.
HI0027CS
Synonyms
CTLA4; CD; CD28; CD152; GSE; ICOS; GRD4; CTLA-4; IDDM12; CELIAC3
Species
Human
Accession
Source
Insect cells
Tag
His tag
Form
Liquid. In Phosphate Buffered Saline (pH 7.4) containing 20% glycerol.
Molecular Mass
14.6kDa (135aa)
18-28KDa (SDS–PAGE under reducing conditions.)
AA Sequence
ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDH HHHHH
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity
> 90% by SDS - PAGE

Usage Guide
Storage
Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration
0.25mg/ml (determined by Absorbance at 280nm)
Warning
For research use only!

BACKGROUND
Background
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
References
Dai F., et al. (2015) Braz J Med Biol Res. 48:629-636.
Ward FJ., et al. (2013) Eur J Immunol. 43:1274-1285.
Romo-Tena J., et al. (2013) Autoimmun Rev. 12:1171-1176.

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