Recombinant Human CTLA4 Protein (His tag) (HI0027CS)

Cat.No.

HI0027CS

Synonyms

CTLA4; CD; CD28; CD152; GSE; ICOS; GRD4; CTLA-4; IDDM12; CELIAC3

Species

Human

Accession

CTLA4

Source

Insect cells

Tag

His tag

Form

Liquid. In Phosphate Buffered Saline (pH 7.4) containing 20% glycerol.

Molecular Mass

14.6kDa (135aa)
18-28KDa (SDS–PAGE under reducing conditions.)

AA Sequence

ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDH HHHHH

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Purity

> 90% by SDS - PAGE

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

References

Dai F., et al. (2015) Braz J Med Biol Res. 48:629-636.
Ward FJ., et al. (2013) Eur J Immunol. 43:1274-1285.
Romo-Tena J., et al. (2013) Autoimmun Rev. 12:1171-1176.