Recombinant Human ANGPT2 Protein(His tag) (HH0136AL)

Recombinant Human ANGPT2 Protein (O15123) (Met 1-Phe 496) with a polyhistidine tag at the C-terminus was expressed in HEK293.

Datasheet

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20ug	$319.00

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PRODUCT INFORMATION

Cat.No.

HH0136AL

Synonyms

ANGPT2; Ang2; ANG-2; ANG2; AGPT2;

Species

Human

Accession

ANGPT2

Source

HEK293

Tag

His

Predicted N Terminal

Tyr 19

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its ability to bind recombinant human Tie2-His in a functional ELISA. Measured by its ability to bind recombinant human Tie2-Fch in a functional ELISA.

Molecular Mass

Recombinant Human Ang2 consists of 489 amino acids and predicts a molecular mass of 56.3 kDa. As a result of glycosylation, the rhAng2 migRates as approximately 60-70 kDa band in SDS-PAGE under reducing conditions.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 92 % by SDS-PAGE.

BACKGROUND

Background

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

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