Recombinant Human CD33 Protein(His tag), Biotinylated (HH0032CL)

Cat.No.

HH0032CL

Synonyms

CD33; p67; SIGLEC 3; SIGLEC3; gp67; SIGLEC-3;

Species

Human

Accession

CD33

Source

HEK293

Tag

His

Form

Lyophilized from sterile PBS, pH7.4, 10% Trehalose.

Molecular Mass

Biotinylated recombinant Human CD33 Protein carries a polyhistidine tag at the C-terminus, and has a calculated MW of 27.6 kDa. The protein migrates as 40-45 kDa on a SDS-PAGE gel under reducing condition due to glycosylation.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

Background

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).