Recombinant Human CD44 Protein(Fc tag)

Recombinant Human CD44 Protein(Fc tag) (HH0204CL)

Recombinant Human CD44 Protein (P16070) (Met1-Pro220) with the Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Size Price Qty
50ug $390.00

PRODUCT INFORMATION

Cat.No.
HH0204CL
Synonyms
CD44; CD44R; CSPG8; HCELL; MC56; Pgp1; epican; LHR; MDU2; MDU3; MIC4; CDW44; HUTCH-I; ECMR-III
Species
Human
Accession
Source
HEK293
Tag
Fc
Predicted N Terminal
Gln 21
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Human CD44/Fc is a disulfide-linked homodimer. The reduced monomer comprises 441 amino acids and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 76 kDa in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 90 % by SDS-PAGE.

Usage Guide

Storage
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.
Reconstitution
Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.
Warning
For research use only!

BACKGROUND

Background
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

INQUIRY

  •   Email: info@profacgen.com
  •   Tel: 1-631-448-8149
  •   Fax: 1-631-938-8127
  •   45-1 Ramsey Road, Shirley, NY 11967, USA