Recombinant Human CD46 Protein(His tag)

Recombinant Human CD46 Protein(His tag) (HH0206CL)

Recombinant Human CD46 Protein (P15529) (Met 1-Asp 328) with a polyhistidine tag at the C-terminus was expressed in HEK293.

Size Price Qty
20ug $390.00

PRODUCT INFORMATION

Cat.No.
HH0206CL
Synonyms
CD46; MCP; AHUS2; MIC10
Species
Human
Accession
Source
HEK293
Tag
His
Predicted N Terminal
Cys 35
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Human CD46 consists of 305 amino acids and has a predicted molecular mass of 34 kDa. As a result of glycosylation, the apparent molecular mass of rh CD46 is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 95 % by SDS-PAGE.

Usage Guide

Storage
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.
Reconstitution
Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.
Warning
For research use only!

BACKGROUND

Background
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

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