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Recombinant Human CD74 Protein(His tag) (HH0173CL)

Recombinant Human CD74 Protein (P04233) (Gln 73-Met 232) with a polyhistidine tag at the N-terminus was expressed in HEK293.

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50ug $429.00
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PRODUCT INFORMATION

Cat.No.
HH0173CL
Synonyms
CD74; p33; HLA-DR-gamma; DHLAG; HLADG; Ia-GAMMA
Species
Human
Accession
Source
HEK293
Tag
His
Predicted N Terminal
Val 19
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Bio-activity
Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5 μg/ml (100 μl/well) can bind biotinylated human CTSL1 with a linear range of 3.2-400 ng/ml.
Molecular Mass
Recombinant Human CD74 consists of 176 amino acids and has a calculated molecular mass of 20.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCD74 is approximately 34 kDa due to glycosylation.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 80 % by SDS-PAGE.

BACKGROUND

Background
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
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