Lyophilized from sterile 50 mM tris, 100 mM glycine, pH7.5, 10% Trehalose.
Molecular Mass
Recombinant Human CD79B Protein is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 41.8 kDa. The reducing protein migrates as 50-65 kDa in SDS-PAGE due to glycosylation.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 92 % by SDS-PAGE.
BACKGROUND
Background
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
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