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Recombinant Human CES2 Protein(His tag) (HH0118CL)

Recombinant Human CES2 Protein (O00748) (Met 1-Leu 559) with a C-terminal polyhistidine tag was expressed in HEK293.

Size Price Qty
10ug $319.00
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PRODUCT INFORMATION

Cat.No.
HH0118CL
Synonyms
CES2; CE 2; CES2A1; iCE; hCE-2; CE-2; PCE-2;
Species
Human
Accession
Source
HEK293
Tag
His
Predicted N Terminal
Gln 27
Form
Lyophilized from sterile 50mM NaAc, 150mM NaCl, 10% Glycerol, pH 5.5, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Human CES2 comprises 544 amino acids with a predicted molecular mass of 60.4 kDa, as estimated in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 95 % by SDS-PAGE.

BACKGROUND

Background
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
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