Lyophilized from sterile 20mM Tris, 500mM NaCl, 0.25M Imi, 20% glycerol, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Human CIRBP consists of 187 amino acids and predicts a molecular mass of 20.5 KDa. It migRates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 90 % by SDS-PAGE.
BACKGROUND
Background
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
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