Recombinant Human CIRBP Protein(His tag) (HE0217CL)

Cat.No.

HE0217CL

Synonyms

CIRBP; CIRP; A18 hnRNP

Accession

CIRBP

Predicted N Terminal

His

Form

Lyophilized from sterile 20mM Tris, 500mM NaCl, 0.25M Imi, 20% glycerol, 5 % trehalose and 5 % mannitol.

Molecular Mass

Recombinant Human CIRBP consists of 187 amino acids and predicts a molecular mass of 20.5 KDa. It migRates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 90 % by SDS-PAGE.

Storage

In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.

Reconstitution

Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Warning

For research use only!

Background

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Tag

His

Species

Human

Source

E. coli

Background

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.