Recombinant Human FAM20C Protein(His tag) (HI0220FL)

Cat.No.

HI0220FL

Synonyms

FAM20C; DMP4; RNS; DMP-4

Species

Human

Accession

FAM20C

Source

Insect cells

Tag

His

Predicted N Terminal

Leu 23

Form

Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol, 5 % trehalose and 5 % mannitol.

Molecular Mass

Recombinant Human FAM20C consists 573 amino acids and predicts a molecular mass of 65.1 kDa.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 85 % by SDS-PAGE.

Background

Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).