Recombinant Human FLT3 Protein(His tag) (HH0124FL)

Recombinant Human FLT3 Protein (P36888) (Met 1-Asn 541) with a C-terminal polyhistidine tag was expressed in HEK293.

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PRODUCT INFORMATION

Cat.No.

HH0124FL

Synonyms

FLT3; CD135; FLK2; STK1; STK-1; FLK-2;

Species

Human

Accession

FLT3

Source

HEK293

Tag

His

Predicted N Terminal

Asn 27

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its ability to bind biotinylated human FLT3L-His in a functional ELISA.

Molecular Mass

Recombinant Human FLT3 consists of 526 amino acids and has a predicted molecular mass of 59.7 kDa. In SDS-PAGE under reducing conditions, it migRates with an apparent molecular mass of 85-95 kDa due to glycosylation.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 85 % by SDS-PAGE.

BACKGROUND

Background

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (PubMed:10535997, PubMed:12615904). Acts as a receptor for vesicular stomatitis virus (PubMed:23589850). In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (PubMed:11100124).

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