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Recombinant Human GPC3 Protein(His tag) (HH0087GL)

Recombinant Human GPC3 Protein (P51654) (Met 1-His 559) with a C-terminal polyhistidine tag was expressed in HEK293.

Size Price Qty
100ug $429.00
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PRODUCT INFORMATION

Cat.No.
HH0087GL
Synonyms
GPC3; glypican 3; SDYS; glypican-3; DGSX; OCI 5; SGB; SGBS; SGBS1; MXR7; OCI-5; GTR2-2;
Species
Human
Accession
Source
HEK293
Tag
His
Predicted N Terminal
Gln 25 & Ser 359
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Bio-activity
Measured by its binding ability in a functional ELISA. Immobilized human GPC3 at 5 μg/ml (100 μl/well) can bind human bFGF / FGF2 with a linear ranger of 0.156-2.5 ng/ml.
Molecular Mass
Recombinant Human GPC3 comprises 546 amino acids and has a predicted molecular mass of 62 kDa.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 87 % by SDS-PAGE.

BACKGROUND

Background
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241).
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