Recombinant Human IL33 Protein (HE0046IL)

Cat.No.

HE0046IL

Synonyms

IL33; interleukin 33; interleukin-33; DVS27; IL-33; IL-1F11; NF-HEV; NFEHEV;

Species

Human

Accession

IL33

Source

E. coli

Predicted N Terminal

Met

Form

Lyophilized from sterile PBS, pH7.4, 10% Trehalose.

Molecular Mass

Recombinant Human IL33 Protein contains no tag, and has a calculated MW of 18.2 kDa. DTT-reduced Protein migrates as 18-20 kDa in SDS-PAGE.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 97 % by SDS-PAGE.

Background

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).