The ED50 as determined by the dose-dependent proliferation of human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of> 1.0 × 10^7 IU/mg.
Molecular Mass
Recombinant Human LIF Protein is a single non-glycosylated polypeptide chain and has a molecular mass of approximately 19.7 kDa.
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 98 % by SDS-PAGE.
BACKGROUND
Background
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
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