Recombinant Human MANF Protein (HE0010ML)

Recombinant Human MANF Protein (P55145) (158 amino acids) with no tag was expressed in E.coli.

Size	Price	Qty
25ug	$319.00

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PRODUCT INFORMATION

Cat.No.

HE0010ML

Synonyms

MANF; ARP; ARMET;

Species

Human

Accession

MANF

Source

E. coli

Form

Lyophilized from sterile PBS, pH 7.4.

Bio-activity

The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 μg/ml, corresponding to a specific activity of> 50 IU/mg.

Molecular Mass

Recombinant Human MANF Protein is a single non-glycosylated polypeptide chain and has a molecular mass of approximately 18.2 kDa.

AA Sequence

LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

BACKGROUND

Background

Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

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