Recombinant Human NGF Protein (HC0166NL)

Recombinant Human NGF Protein (P01138) (Ser 122-Arg 239) with no tag was expressed in CHO.

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100ug	$539.00

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PRODUCT INFORMATION

Cat.No.

HC0166NL

Synonyms

NGF; NGFB; HSAN5; Beta-NGF

Species

Human

Accession

NGF

Source

CHO

Predicted N Terminal

Ser 122

Form

Lyophilized from sterile 20mM NaAc, 150mM NaCl, pH 5.5, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2-2 ng/ml.

Molecular Mass

Recombinant Human β-NGF consists of 118 amino acids and has a predicted molecular mass of 13.2 kDa. β-NGF exists as a non-disulfide linked homodimer in solution.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

BACKGROUND

Background

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

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