Recombinant Human S100A7 Protein (HE0175SL)

Cat.No.

HE0175SL

Synonyms

S100A7; protein S100-A7; S100A7c; psoriasin 1; PSOR1

Species

Human

Accession

S100A7

Source

E. coli

Predicted N Terminal

Met

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Molecular Mass

Recombinant Human S100A7 consisting of 101 amino acids and migRates as an 11.6 kDa band in SDS-PAGE under reducing conditions as predicted.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 98 % by SDS-PAGE.

Background

S100A7, also known as Psoriasin, is a 11-12 kDa member of the S100 family of EF hand calcium binding proteins. Human S100A7 shares 32% amino acid sequence identity with mouse S100A7A, the closest related protein in mouse. It is acetylated at the N-terminus and binds both calcium and zinc ions. S100A7 is up-regulated in keratinocytes of psoriasis and atopic dermatitis lesions, as well as in epithelial cells of the tongue, eye, and female genital tract. Its up-regulation can be induced by bacterial exposure, inflammatory cytokines, or epidermal barrier disruption. S100A7 supports epithelial integrity through killing E. coli by sequestration of zinc and through inducing the up-regulation of tight junction proteins. The interaction of S100A7 with RAGE promotes the migration of immune cells and the infiltration of macrophages into tumor sites.