Recombinant Human SLAMF7 Protein(Fc tag) (HH0059SL)

Cat.No.

HH0059SL

Synonyms

SLAMF7; CD319; CRACC; CS1; protein 19A;

Species

Human

Accession

SLAMF7

Source

HEK293

Tag

Fc

Predicted N Terminal

Ser 23

Form

Lyophilized from sterile 50 mM tris, 100 mM glycine, pH7.5, 10% Trehalose.

Molecular Mass

Recombinant Human SLAMF7 Protein is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 49 kDa. DTT-reduced Protein migrates as 60-67 kDa in SDS-PAGE due to glycosylation.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

Background

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.