Lyophilized from sterile 50 mM tris, 100 mM glycine, pH7.5, 10% Trehalose.
Molecular Mass
Recombinant Human TIGIT Protein is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 39.7 kDa. The reducing protein migrates as 40-55 kDa in SDS-PAGE due to glycosylation.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 92 % by SDS-PAGE.
BACKGROUND
Background
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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