Recombinant Human VEGFA Protein, Biotinylated (HH0062VL)

Cat.No.

HH0062VL

Synonyms

VEGFA; VEGF A; VPF; VEGF; MVCD1;

Species

Human

Accession

VEGFA

Source

HEK293

Form

Lyophilized from sterile PBS, pH7.4, 10% Trehalose.

Molecular Mass

Biotinylated recombinant Human VEGFA Protein does NOT contain any epitope tags. The protein migrates as 24 kDa (monomer) on a SDS-PAGE gel under reducing condition due to glycosylation and 43-50 kDa under non-reducing condition.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

Background

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.