Recombinant Human PTH Protein (HE0010PS)
Recombinant Human PTH Protein (NP_000306) (32-115aa) was expressed in E.coli.
| Size | Price | Qty |
|---|---|---|
| 10ug | $165.00 |
PRODUCT INFORMATION
Cat.No.
HE0010PS
Synonyms
PTH; parathyroid hormone; parathormone; parathyrin; PTH1
Species
Human
Accession
Source
E. coli
Form
Liquid. In phosphate-buffered Saline(pH 7.4) containing 2 mM EDTA
Bio-activity
Measured by its ability to induce cAMP accumulation in MC3T3/E1 mouse preosteoblast cells. The ED50 for this effect is less than or equal to 50 ng/ml.
Molecular Mass
9.55 kDa (85 aa), confirmed by MALDI-TOF
AA Sequence
MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE
BACKGROUND
Background
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants.
References
Hodsman AB. et al. (2003) J. Clin. Endocrinol. Metab. 88(11), 5212-20.
Wingender E., et al. (1989) J. Biol. Chem. 264(8),4367-73.
Wingender E., et al. (1989) J. Biol. Chem. 264(8),4367-73.
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