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Recombinant Human S100B Protein(His tag) (HE0007SS)

Recombinant Human S100B Protein (NP_006263) (1-92aa) was expressed in E.coli.
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Size:100ug
Price:$450.00
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PRODUCT INFORMATION
Cat.No.
HE0007SS
Synonyms
S100B; protein S100-B; S100beta; NEF; S100; S100-B
Species
Human
Accession
Source
E. coli
Form
Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol
Molecular Mass
10.7kDa (92aa)
AA Sequence
MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFEHE
Purity
> 95% by SDS - PAGE

Usage Guide
Storage
Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration
1mg/ml (determined by Bradford assay)
Warning
For research use only!

BACKGROUND
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
References
Gilquin B., et al. (2010) Mol Cell Biol. 30(11): 2724-36.
Yamaguchi F., et al. (2012) J Biol Chem. 287(17): 13787-98.

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