Recombinant Human S100B Protein(His tag) (HE0007SS)

Cat.No.

HE0007SS

Synonyms

S100B; protein S100-B; S100beta; NEF; S100; S100-B

Species

Human

Accession

S100B

Source

E. coli

Form

Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol

Molecular Mass

10.7kDa (92aa)

AA Sequence

MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFEHE

Purity

> 95% by SDS - PAGE

Background

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

References

Gilquin B., et al. (2010) Mol Cell Biol. 30(11): 2724-36.
Yamaguchi F., et al. (2012) J Biol Chem. 287(17): 13787-98.