Recombinant Human VEGFC Protein(His tag) (HI0002VS)

1. Koltowska, Katarzyna; Lagendijk, Anne Karine; Pichol-Thievend, Cathy; et al. Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. CELL REPORTS, 13-9, 1828-1841.

"Vegfc drives cell division and Prox1 expression in lymphatic daughter cells, coupling signaling dynamics with daughter cell fate restriction and precursor division."

2. Koltowska, Katarzyna; Paterson, Scott; Bower, Neil I.; et al. mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. GENES & DEVELOPMENT, 29-15, 1618-1630.

"Mechanistically, Vegfc signaling increases mafba expression to control downstream transcription, and this regulatory relationship is dependent on the activity of SoxF transcription factors, which are essential for mafba expression in venous endothelium. Here we identify an indispensable Vegfc-SoxF-Mafba pathway in lymphatic development."

3.Jung, Michaela; Oeren, Bilge; Mora, Javier; et al. Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine-1-phosphate promotes lymphangiogenesis and tumor metastasis, SCIENCE SIGNALING, 9-434.

"Conditioned medium from coculture experiments indicated that the release of LCN2 from macrophages induced tube formation and proliferation in cultures of primary human lymphatic endothelial cells in amanner dependent on the kinase PI3K and subsequent induction of the growth factor VEGFC, which functioned as an autocrine signal stimulating the receptor VEGFR3."