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Recombinant Mouse Adipoq Protein(His tag) (MH0248AL)

Recombinant Mouse Adipoq Protein (Q60994) (Met 1-Asn 247) with a C-terminal polyhistidine tag was expressed in HEK293.

Size Price Qty
50ug $429.00
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PRODUCT INFORMATION

Cat.No.
MH0248AL
Synonyms
ADIPOQ; APN; Acdc; apM1; GBP28; adipo; Acrp30
Species
Mouse
Accession
Source
HEK293
Tag
His
Predicted N Terminal
Glu 18
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Mouse ADIPOQ comprises 241 amino acids and has a calculated molecular mass of 26.4 kDa. As a result of glycosylation, Recombinant protein migRates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 95 % by SDS-PAGE.

BACKGROUND

Background
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
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