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Recombinant Mouse Cd226 Protein(Fc-His tag) (MH0237CL)

Recombinant Mouse Cd226 Protein (Q8K4F0) (Met 1-Pro 254) with polyhistidine-tagged Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Size Price Qty
50ug $429.00
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PRODUCT INFORMATION

Cat.No.
MH0237CL
Synonyms
CD226; CD226 antigen; Pta1; DNAM1; DNAM-1; TLiSA1
Species
Mouse
Accession
Source
HEK293
Tag
Fc-His
Predicted N Terminal
Glu 19
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Bio-activity
Measured by its ability to bind recombinant mouse CD155/PVR. Immobilized recombinant mouse CD155/PVR at 1 μg/ml (100 μl/well) can bind recombinant mouse CD226/DNAM-1 with a linear range of 0.78-100 ng/ml.
Molecular Mass
Recombinant Mouse DNAM1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 484 amino acids and has a predicted molecular mass of 55 kDa. As a result of glycosylation, rm DNAM1/Fc monomer migRates with an apparent molecular mass of 70-80 kDa in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 97 % by SDS-PAGE.

BACKGROUND

Background
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
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