Recombinant Mouse Tlr3 Protein(His tag)

Recombinant Mouse Tlr3 Protein(His tag) (MH0232TL)

Recombinant Mouse Tlr3 Protein (Q99MB1) (Met 1-Leu 705) with a C-terminal polyhistidine tag was expressed in HEK293.

Size Price Qty
50ug $390.00

PRODUCT INFORMATION

Cat.No.
MH0232TL
Synonyms
TLR3; toll-like receptor 3
Species
Mouse
Accession
Source
HEK293
Tag
His
Predicted N Terminal
Thr 26
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Mouse TLR3 consists of 691 amino acids and has a calculated molecular mass of 78.7 kDa. As a result of glycosylation, Recombinant protein migRates as an approximately 100-110 kDa protein in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 97 % by SDS-PAGE.

Usage Guide

Storage
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.
Reconstitution
Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.
Warning
For research use only!

BACKGROUND

Background
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).

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