Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Mouse TREM2 consists of 161 amino acids with the predicted molecular mass of 18 kDa. As a result of glycosylation, the apparent molecular mass of rmTREM2 is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 95 % by SDS-PAGE.
BACKGROUND
Background
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
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