Recombinant Mouse Vsig4 Protein(His tag) (MH0234VL)

Cat.No.

MH0234VL

Synonyms

VSIG4; CRIg

Species

Mouse

Accession

Vsig4

Source

HEK293

Tag

His

Predicted N Terminal

His 20

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Molecular Mass

Recombinant Mouse VSIG4 consists of 179 amino acids and has a predicted molecular mass of 20.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmVSIG4 is approximately 35 kDa due to glycosylation.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

Background

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.