Recombinant Mouse F3 Protein (hIgG-His tag) (MI0020FS)

Cat.No.

MI0020FS

Synonyms

F3; coagulation factor III; tissue factor; TF; Cf3; Cf-3; CD142; AA409063;

Species

Mouse

Source

Insect cells

Tag

His tag

Form

Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.

Molecular Mass

26.4kDa (232aa)
28-40KDa (SDS–PAGE under reducing conditions.)

AA Sequence

ADPAGIPEKA FNLTWISTDF KTILEWQPKP TNYTYTVQIS DRSRNWKNKC FSTTDTECDL TDEIVKDVTW AYEAKVLSVP RRNSVHGDGDQLVIHGEEPP FTNAPKFLPY RDTNLGQPVI QQFEQDGRKL NVVVKDSLTL VRKNGTFLTL RQVFGKDLGY IITYRKGSST GKKTNITNTNEFSIDVEEGV SYCFFVQAMI FSRKTNQNSP GSSTVCTEQW KSFLGEHHHH HH

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Purity

> 95% by SDS - PAGE

Background

This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis.

References

Versteeg HH., et al. (2003) Carcinogenesis. 24:1009-1013.
Morrissey JH., et al. (2004) Int J Hematol. 79:103-108.