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Recombinant Rhesus CD22 Protein(Fc tag) (RH0275CL)

Recombinant Rhesus CD22 Protein (F6W485) (Met1-Arg686) with the Fc region of human IgG1 at the C-terminus was expressed in HEK293.
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Size:20ug
Price:$390.00
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PRODUCT INFORMATION
Cat.No.
RH0275CL
Synonyms
CD22; SIGLEC2; BL-CAM; Leu-14
Species
Rhesus
Accession
Source
HEK293
Tag
Fc
Predicted N Terminal
Ser 20
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.
Molecular Mass
Recombinant Rhesus CD22 comprises 908 amino acids and has a calculated molecular mass of 102.1 KDa.
Endotoxin
< 1.0 EU per 1 microgram of protein (determined by LAL method).
Purity
> 90 % by SDS-PAGE.

Usage Guide
Storage
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.
Reconstitution
Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.
Warning
For research use only!

BACKGROUND
Background
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

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